Thursday 29 September 2011

Tramadol | Tramadol hydrochloride (Ultram, Tramal)


Tramadol hydrochloride (Ultram, Tramal) is a centrally acting opioid analgesic, used in treating moderate to severe pain. This drug is very useful and has various applications like in  treatment for restless legs syndrome and fibromyalgia. It was developed by pharma company Gmbh in 1970's. Tramadol is used similarly to codeine, to treat moderate to moderately severe pain.

                                                        Structure of Tramadol

Tramadol is available in Tablets, Capsules, Powder, Liquid solution etc.Tramadol has been regularly used in the form of an ingredient in multi-agent topical gels, creams, and solutions for nerve pain, rectal foam, concentrated retention enema, and a skin plaster (transdermal patch) quite similar to those used with lidocaine. The maximum dosage per day is 400 mg for oral use and 600 mg for parenteral use. Certain manufacturers or formulations have lower maximum doses.

Chemical Formula of tramadol is: C16H25NO2

                                                          Tramadol Tablets

The most commonly reported adverse drug reactions are nausea, vomiting, sweating, itching and constipation.Tramadol has a characteristic and unpleasant taste which is mildly bitter but much less so than morphine and codeine. Oral and sublingual drops and liquid preparations come with and without added flavoring.Tramadol has been regularly used in the form of an ingredient in multi-agent topical gels, creams, and solutions for nerve pain, rectal foam, concentrated retention enema, and a skin plaster (transdermal patch) quite similar to those used with lidocaine.

                                                       Side Effects of Tramadol

The warnings include more compelling language regarding the addictive potential of tramadol, the possibility of difficulty breathing while on the medication, a new list of more serious side effects, and a notice that tramadol is not to be used in place of opiate medications for addicts. Tramadol is also not to be used in efforts to wean addict patients from opiate drugs, nor to be used to manage long-term opiate addiction.

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